• P-ISSN 2277-3525 E-ISSN 2582-7901

Journal of Multidisciplinary
Dental Research

Article

Journal of Multidisciplinary Dental Research

DOI: 10.38138/JMDR/v9i1.22.41

Volume: 9, Issue: 1, Pages: 1-9

Original Article

Health Related Quality of Life of Oral Cancer Patients Who Receive Radiotherapy With or Without Chemotherapy in Sri Lanka

Shamini Kosgallana ​✉ 1,2 , Prasanna Jayasekara 3 , Prasad Abeysinghe 4 , Ratilal Lalloo 5

1 Post MD trainee, Ministry of Health, Sri Lanka
2 Visiting Academic, School of Dentistry, University of Queensland, QLD, 4006, Australia
3 Consultant in Community Dentistry, Research & Surveillance Unit, Institute of Oral Health Maharagama, Sri Lanka
4 Oncologist, Apeksha Hospital Maharagama, Sri Lanka
5 Associate Professor and Director Teaching and Learning, School of Dentistry, University of Queensland, QLD, 4006, Australia

Corresponding author ✉:  [email protected]

Received Date:12 September 2022, Accepted Date:01 December 2022, Published Date:30 June 2023

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Patient reported health related quality of life outcomes have considered as valid information when deciding the treatments and making protocols in cancer management. The aim of the study was to assess the health-related quality of life of oral cancer patients who receive radiotherapy (RT) with or without chemotherapy and the changes in health-related quality of life. A prospective study was conducted among 90 oral cancer patients who receive RT with or without chemotherapy. Two European Organization for the Research and Treatment of Cancer Quality of Life Questionnaires: EORTC QLQ-C30 and EORTC QLQ-H&N35, were used to assess health-related quality of life before RT, during the last week of RT and three months after RT. The majority were males (88%) and 68% were aged 50-69. The median scores of all the domains and items in EORTC QLQ-H&N35 and symptom domains and items in EORTC QLQ-C30 were higher during the last week of RT compared to the baseline (most scores were zero). Except for ‘Appetite loss’ item, all the symptom domains and items scores were lower at three months after RT than the median scores during last week of RT. Statistically significant differences were observed in almost all the changes in health-related quality of life between three time frames (p<0.05). Health-related quality of life of oral cancer patients declined due to RT from baseline to the last week of RT and improved three months after RT from last week of RT but had not returned to the baseline level.

Keywords: Oral cancer, Health related quality of life, Radiotherapy, EORTC QLQ-H&N35, EORTC QLQ-C30

References

  1. Scully C. Statement on mouth cancer diagnosis and prevention. Journal of the Bahrain Medical Society. 2014;25(1):48–49. Available from: https://doi.org/10.26715/jbms.p25_11
  2. Joshi P, Dutta S, Chaturvedi P, Nair S. Head and Neck Cancers in Developing Countries. Rambam Maimonides Medical Journal. 2014;5(2):1–6. Available from: https://www.rmmj.org.il/userimages/374/1/PublishFiles/393Article.pdf
  3. Aruna DS, Prasad KVV, Shavi GR, Ariga J, Rajesh G, Krishna M. Retrospective Study on Risk Habits among Oral Cancer Patients in Karnataka Cancer Therapy and Research Institute, Hubli, India. Asian Pacific Journal of Cancer Prevention. 2011;12:1561–1566. Available from: https://journal.waocp.org/article_25732_2c91eba92cad30931fbef03027576543.pdf
  4. Huang SH, O´Sullivan B. Oral cancer: Current role of radiotherapy and chemotherapy. Medicina Oral Patología Oral y Cirugia Bucal. 2013;18(2):e233–e240. Available from: http://www.medicinaoral.com/pubmed/medoralv18_i2_p233.pdf
  5. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2018;68(6):394–424. Available from: https://doi.org/10.3322/caac.21492
  7. Ord RA, Blanchaert RH. Current management of oral cancer. A multidisciplinary approach. The Journal of the American Dental Association. 2001;132(Supplement 1):19S–23S. Available from: https://doi.org/10.14219/jada.archive.2001.0384
  8. Madhulaxmi M, Iyer K, Periasamy R, Gajendran P, Lakshmi T. Role of cisplatin in oral squamous cell carcinoma - A review. Journal of Advanced Pharmacy Education & Research. 2017;7(2):39–42. Available from: https://japer.in/article/role-of-cisplatin-in-oral-squamous-cell-carcinoma-a-review
  9. Fang FMM, Tsai WLL, Chien CYY, Chiu HC, Wang CJ, Chen HC, et al. Changing Quality of Life in Patients with Advanced Head and Neck Cancer after Primary Radiotherapy or Chemoradiation. Oncology. 2005;68(4-6):405–413. Available from: https://doi.org/10.1159/000086982
  10. Bottomley A. The Cancer Patient and Quality of Life. The Oncologist. 2002;7(2):120–125. Available from: https://doi.org/10.1634/theoncologist.7-2-120
  11. Yucel B, Akkaş EA, Okur Y, Eren AA, Eren MF, Karapınar H, et al. The impact of radiotherapy on quality of life for cancer patients: a longitudinal study. Supportive Care in Cancer. 2014;22:2479–2487. Available from: https://doi.org/10.1007/s00520-014-2235-y
  12. Jham BC, Freire ARdS. Oral complications of radiotherapy in the head and neck. Brazilian Journal of Otorhinolaryngology. 2006;72(5):704–708. Available from: https://doi.org/10.1016/S1808-8694(15)31029-6
  13. Kumar D, Rastogi N. Oral Complications and Its Management during Radiotherapy. International Journal of Head and Neck Surgery. 2011;2(2):109–113. Available from: https://www.ijhns.com/doi/pdf/10.5005/jp-journals-10001-1062
  14. Sischo L, Broder HL. Oral Health-related Quality of Life : What , Why , How , and Future Implications. Journal of Dental Research. 2011;90(11):1264–1270. Available from: https://doi.org/10.1177/0022034511399918
  15. Velikova G, Coens C, Efficace F, Greimel E, Groenvold M, Johnson C, et al. Health-Related Quality of Life in EORTC clinical trials — 30 years of progress from methodological developments to making a real impact on oncology practice. European Journal of Cancer Supplements. 2012;10(1):141–149. Available from: https://doi.org/10.1016/S1359-6349(12)70023-X
  16. Borggreven PA, Leeuw IMVD, Muller MJ, Heiligers MLCH, Bree RD, Aaronson NK, et al. Quality of life and functional status in patients with cancer of the oral cavity and oropharynx: pretreatment values of a prospective study. European Archives of Oto-Rhino-Laryngology. 2007;264:651–657. Available from: https://doi.org/10.1007/s00405-007-0249-5
  18. Boscolo-Rizzo P, Maronato F, Marchiori C, Gava A, Mosto MCD. Long-Term Quality of Life After Total Laryngectomy and Postoperative Radiotherapy Versus Concurrent Chemoradiotherapy for Laryngeal Preservation. The Laryngoscope. 2008;118(2):300–306. Available from: https://doi.org/10.1097/MLG.0b013e31815a9ed3
  19. Shah JP, Gil Z. Current concepts in management of oral cancer – Surgery. Oral Oncology. 2009;45(4-5):394–401. Available from: https://doi.org/10.1016/j.oraloncology.2008.05.017
  20. Arslan SS, Demir N, Cengiz M, Karaduman AA. Swallowing and quality of life outcomes early after radiation therapy in head and neck cancer patients. Türk Fizyoterapi ve Rehabilitasyon Dergisi/Turkish Journal of Physiotherapy and Rehabilitation. 2015;26(20):128–134. Available from: https://doi.org/10.7603/s40680-015-0020-6
  21. Urdaniz JIA, Vega FADL, Burgaleta AM, García RV, Aguillo MM, Pascual ES, et al. Quality of life in patients with locally advanced head and neck cancer treated with chemoradiotherapy. Comparison of two protocols using the EORTC questionnaires (QLQ-C30, H&N35) Clinical and Translational Oncology. 2005;7:398–403. Available from: https://doi.org/10.1007/BF02716585
  22. Osoba D, Rodrigues G, Myles J, Zee B, Pater J. Interpreting the significance of changes in health-related quality-of-life scores. Journal of Clinical Oncology. 1998;16(1):139–144. Available from: https://ascopubs.org/doi/10.1200/JCO.1998.16.1.139
  24. Leung SW, Lee TF, Chien CY, Chao PJ, Tsai WL, Fang FM. Health-related Quality of life in 640 head and neck cancer survivors after radiotherapy using EORTC QLQ-C30 and QLQ-H & N35 questionnaires. BMC Cancer. 2011;11(128):1–10. Available from: https://doi.org/10.1186/1471-2407-11-128
  25. Braam PM, Roesink JM, Raaijmakers CPJ, Busschers WB, Terhaard CHJ. Quality of life and salivary output in patients with head-and-neck cancer five years after radiotherapy. Radiation Oncology. 2007;2(3):1–8. Available from: https://doi.org/10.1186/1748-717X-2-3
  26. Pow EHN, Kwong DLW, Mcmillan AS, Wong MCM, Sham JST, Leung LHT, et al. Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized controlled clinical trial. International Journal of Radiation Oncology, Biology, Physics. 2006;66(4):981–991. Available from: https://doi.org/10.1016/j.ijrobp.2006.06.013
  27. Ngeow WC, Chai WL, Rahman RA, Ramli R. Managing complications of radiation therapy in head and neck cancer patients: Part II. Management of mucositis. Singapore Dental Journal. 2006;28(1):16–18. Available from: https://pubmed.ncbi.nlm.nih.gov/17378337/
  28. Rosenthal DI, Trotti A. Strategies for Managing Radiation-Induced Mucositis in Head and Neck Cancer. Seminars in Radiation Oncology. 2009;19(1):29–34. Available from: https://doi.org/10.1016/j.semradonc.2008.09.006
  29. Kumar D, Rastogi N. Oral Complications and Its Management during Radiotherapy. International Journal of Head and Neck Surgery. 2011;2(2):109–113. Available from: https://www.ijhns.com/doi/pdf/10.5005/jp-journals-10001-1062

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© 2023 Published by International Dental Educationists’ Association (IDEA). This is an open-access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/)

  • 30 June 2023
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