• P-ISSN 2277-3525 E-ISSN 2582-7901

Journal of Multidisciplinary
Dental Research

Article

Journal of Multidisciplinary Dental Research

DOI: 10.38138/JMDR/v10i2.lin

Volume: 10, Issue: 2, Pages: 81-86

Review Article

Microbiome and Cancer in the Oral Cavity: A Bioinformatics Perspective

Yu-Cheng Lin1,2, Ding-Han Wang1,2, Cheng-Chieh Yang1,3, Ming-Lun Hsu1,∗

1Department of Dentistry, College of Dentistry, National Yang Ming Chiao Tung University, No. 155, Section 2, Linong St.,, Taipei, 112, Taiwan
2Oral Medicine Innovation Center [OMIC], National Yang Ming Chiao Tung University, Taipei, Taiwan
3Department of Stomatology, Oral & Maxillofacial Surgery, Taipei Veterans General Hospital, Taipei, Taiwan

*Corresponding Author
Email: [email protected]

Received Date:02 November 2024, Accepted Date:11 December 2024, Published Date:30 December 2024

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The relationship between microbiome and cancer in the oral cavity has been under intense scrutiny over the past decade due to the advancement in next-generation sequencing. However, rapid accumulation of sequencing data may yield more questions than answers. Although such inconclusiveness can be attributed to the heterogeneous nature of biological phenomena, inconsistency in complex bioinformatics analysis may also play a role. In this review, we aim to provide a comprehensive and concise overview of common bioinformatics analysis processes used in microbiome studies focusing on 16S rDNA sequencing. By taking this bioinformatics perspective as a conceptual framework, we further discussed the consistency and discrepancies among numerous studies on the relationship between oral microbiome and oral cancer. This review aims to elucidate the bioinformatics methodologies and their impact on the current understanding of the oral microbiome's role in cancer development.

Keywords: Oral cavity, Bioinformatics, Microbiome

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© 2024 Published by International Dental Educationists’ Association (IDEA). This is an open-access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/) 

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