• P-ISSN 2277-3525 E-ISSN 2582-7901

Journal of Multidisciplinary
Dental Research

Article

Journal of Multidisciplinary Dental Research

DOI: 10.38138/JMDR/v9i1.22.51

Volume: 9, Issue: 1, Pages: 43-47

Review Article

Animal Models in Periodontology: A Review

Abdul Naeem​ ✉ 1 , Vinita Boloor 2 , K S Rajesh 3 , Shashikanth Hegde 4 , Anupama Rao 2

1 Postgraduate, Department of Periodontology, Yenepoya Dental College, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka, India
2 Additional Professor, Department of Periodontology, Yenepoya Dental College, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka, India
3 Professor and Head of Department of Periodontology, Yenepoya Dental College, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka, India
4 Professor, Department of Periodontology, Yenepoya Dental College, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka, India

Corresponding author ✉: [email protected]

Received Date:14 December 2022, Accepted Date:03 January 2023, Published Date:30 June 2023

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

In periodontal research, animal studies are complementary to in vitro experiments prior to testing new treatments. Animal models should make possible the validation of hypotheses and prove the safety and efficacy of new regenerating approaches using biomaterials, growth factors or stem cells. Rats, hamsters, rabbits, ferrets, dogs, and primates are just a few of the many kinds of animals that have been utilised as models for human periodontal illnesses and therapies. However, animal anatomy and physiopathology differ from those of humans, making it challenging to assess novel treatments. Major periodontal diseases (gingivitis and periodontitis), their development, and innovative surgical procedures have all been studied using experimental models. This review's objective is to draw attention to the animal models that are available for dentistry research.

Keywords: Periodontal disease, Animal models, Biomaterials, Periodontal surgery

References

  1. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. The lancet. 2005;366(9499):1809–1820. Available from: https://doi.org/10.1016/S0140-6736(05)67728-8
  3. Held JR. Appropriate animal models. Annals of the New York Academy of Sciences. 1983;406(1):13–19. Available from: https://doi.org/10.1111/j.1749-6632.1983.tb53481.x
  4. Struillou X, Boutigny H, Soueidan A, Layrolle P. Experimental Animal Models in Periodontology: A Review. The Open Dentistry Journal. 2010;4:37–47. Available from: https://opendentistryjournal.com/VOLUME/4/PAGE/37/
  5. Weinberg MA, Bral M. Laboratory animal models in periodontology. Journal of Clinical Periodontology. 1999;26(6):335–340. Available from: https://doi.org/10.1034/j.1600-051X.1999.260601.x
  6. Davidson MK, Lindsey JR, Davis JK. Requirements and selection of an animal model. Israel Journal of Medical Sciences. 1987;23(6):551–555. Available from: https://pubmed.ncbi.nlm.nih.gov/3312096/
  7. Pal TK. Animal experimentations: Part I: General considerations. Journal of the International Clinical Dental Research Organization. 2015;7(1):7–10. Available from: https://journals.lww.com/jicd/Fulltext/2015/07010/Animal_experimentations__Part_I__General.4.aspx
  9. Kim Y, Hamada N, Takahashi Y, Sasaguri K, Tsukinoki K, Onozuka M, et al. Cervical sympathectomy causes alveolar bone loss in an experimental rat model. Journal of Periodontal Research. 2009;44(6):695–703. Available from: https://doi.org/10.1111/j.1600-0765.2008.01177.x
  12. Pereira S, Tettamanti M. Ahimsa and alternatives - The concept of the 4th R. The CPCSEA in India. ALTEX - Alternatives to animal experimentation. 2005;22(1):3–6. Available from: https://www.altex.org/index.php/altex/article/view/921
  13. Champagne C, Yoshinari N, Oetjen JA, Riché EL, Beck JD, Offenbacher S. Gender differences in systemic inflammation and atheroma formation following <i>Porphyromonas gingivalis</i> infection in heterozygous apolipoprotein E-deficient mice. Journal of Periodontal Research. 2009;44(5):569–577. Available from: https://doi.org/10.1111/j.1600-0765.2008.01156.x
  14. Gruber FP, Hartung T. Alternatives to animal experimentation in basic research. ALTEX - Alternatives to animal experimentation. 2004;21(Supp. 1):3–31. Available from: https://www.altex.org/index.php/altex/article/view/2182
  16. Nomura T, Katsuki M, Yokoyama M, Tajima Y. Future perspectives in the development of new animal models. Progress in clinical and biological research. 1987;229:337–353. Available from: https://pubmed.ncbi.nlm.nih.gov/3474667/

COPYRIGHT

© 2023 Published by International Dental Educationists’ Association (IDEA). This is an open-access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/) 

  • 10 July 2023
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