<?xml version='1.0' encoding='UTF-8'?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.1d1 20130915//EN" "JATS-journalpublishing1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta id="journal-meta-5c7dbbf243d94de7abbceae5977c723a">
      <journal-id journal-id-type="nlm-ta">Sciresol</journal-id>
      <journal-id journal-id-type="publisher-id">Sciresol</journal-id>
      <journal-id journal-id-type="journal_submission_guidelines">https://jmdr-idea.com/author-guidelines</journal-id>
      <journal-title-group>
        <journal-title>Journal of Multidisciplinary Dental Research</journal-title>
      </journal-title-group>
      <issn publication-format="print"/>
    </journal-meta>
    <article-meta id="article-meta-d141d773607840619bb04b3307720596">
      <article-id pub-id-type="doi">10.38138/JMDR/v8i2.22.40</article-id>
      <article-categories>
        <subj-group>
          <subject>Review Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title id="article-title-d3e3dc03ab9046a5a95795c52262f863">Brief Overview on Probiotics</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name id="name-999941e5bfea433a92d3753bc69dbbe1">
            <surname>Zafna</surname>
            <given-names>Aesha</given-names>
          </name>
          <xref id="xref-dce0417f8751452b91e24c546cc2f284" rid="aff-c16f9f980e4c40049c6c327d838f520b" ref-type="aff">1</xref>
        </contrib>
        <contrib contrib-type="author" corresp="yes">
          <name id="name-1cc01ada9e254970a9b0b4b3043e3422">
            <surname>Vijayan</surname>
            <given-names>Vidhya</given-names>
          </name>
          <email>vidhya@kmctdentalcollege.org</email>
          <xref id="xref-a3c50e730f32416aa4ef183e3e2ee54f" rid="aff-40b6ab05400a433784f19454c966b8ac" ref-type="aff">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name id="name-1f0bedd5069e4605a3eda86e32decfff">
            <surname>Darshana</surname>
            <given-names>V</given-names>
          </name>
          <xref id="xref-eabf7def77d947b7976537ea3af46074" rid="aff-40b6ab05400a433784f19454c966b8ac" ref-type="aff">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name id="name-b647f798060f488384d56c4d8b9ccf2b">
            <surname>Sathyan</surname>
            <given-names>Anjali</given-names>
          </name>
          <xref id="xref-5458b51920e94792b351e4e5409de479" rid="aff-5efe68041dd0416296cc7743010021fb" ref-type="aff">3</xref>
        </contrib>
        <contrib contrib-type="author">
          <name id="name-f45cd0f9f57f45d7b3416a79ccd62aad">
            <surname>Vaishnavi</surname>
            <given-names>J S</given-names>
          </name>
          <xref id="xref-8ec5d2cd1c3f423fa26e56a58cb41303" rid="aff-5efe68041dd0416296cc7743010021fb" ref-type="aff">3</xref>
        </contrib>
        <aff id="aff-c16f9f980e4c40049c6c327d838f520b">
          <institution>Assistant Professor, Department of Public Health Dentistry, Vydehi Institute of Dental Sciences</institution>
          <addr-line>Bengaluru, Karnataka</addr-line>
          <country country="IN">India</country>
        </aff>
        <aff id="aff-40b6ab05400a433784f19454c966b8ac">
          <institution>Assistant Professor, Department of Pediatric and Preventive Dentistry, KMCT Dental College</institution>
          <addr-line>Mukkom, Calicut</addr-line>
          <country country="IN">India</country>
        </aff>
        <aff id="aff-5efe68041dd0416296cc7743010021fb">
          <institution>Lecturer, Department of Pediatric and Preventive Dentistry, KMCT Dental College</institution>
          <addr-line>Mukkom, Calicut</addr-line>
          <country country="IN">India</country>
        </aff>
      </contrib-group>
      <volume>8</volume>
      <issue>2</issue>
      <fpage>72</fpage>
      <permissions>
        <copyright-year>2022</copyright-year>
      </permissions>
      <abstract id="abstract-abstract-title-8b6492bc07c74a3b829e5a06f871a9b6">
        <title id="abstract-title-8b6492bc07c74a3b829e5a06f871a9b6">Abstract</title>
        <p id="paragraph-a3ea339baf384cb1b3de3cbae9d2516f">Probiotics are generally safe to consume, but may cause bacteria-host interactions and side effects in few cases. Bacteria play an essential role in maturation of the intestine, development and control of the immune system. In a newborn, this bacterial flora is transferred from mother through breastfeeding. The imbalances of oral microbial flora are responsible for various oral diseases. Probiotics are live microorganisms that provide health benefits when consumed. Probiotics are generally safe to consume, but may cause bacteria-host interactions and side effects in few cases. The recent researches review that the judicious use of probiotics play a vital role in limiting these diseases. Probiotics are generally safe to consume, but may cause bacteria-host interactions and side effects in few cases. </p>
        <p id="p-df68c98c1825"/>
      </abstract>
      <kwd-group id="kwd-group-fc38cd22aca6406ba6a4957e65996d45">
        <title>Keywords</title>
        <kwd>Probiotics</kwd>
        <kwd>Microbial flora</kwd>
        <kwd>Oral health</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec>
      <title id="title-df1a2eedbde94fadb9831c0083c60bf3">Introduction</title>
      <p id="paragraph-4beeed0b82e54ee9a8ee964cc8ab08be">The proper functioning of the digestive ecosystem is affected by the microbial load in the diet. The interaction of food and the gut microbiota determines the status of healthy living. Probiotics have been associated with gut health, and focused on the prevention or treatment of gastrointestinal infections and diseases. During the last few years, several authors have suggested that probiotic bacteria originally planned for gut health could also be beneficial to oral health <xref id="xref-4134700b16e6427a9551e44752748ef7" rid="R162124026653877" ref-type="bibr">1</xref>.  Dental caries and periodontal disease are the most prevalent diseases that affect oral health. </p>
      <p id="paragraph-546a41fd330b4f47912002f435d44a9d">Effective antimicrobial treatment modulates the microbial ecology of dental plaque in a pathogen-targeted manner. The non-selective antibacterial killing cause imbalance of the ecology of normal oral flora and results in persistent pathogenesis <xref id="xref-dc8e44f816ec45b483a7fbfab7fb382a" rid="R162124026653875" ref-type="bibr">2</xref>. Eliminating the pathogenic organisms and maintaining the favourable microbes with probiotics for preventing oral diseases has become a recent trend in dentistry. </p>
    </sec>
    <sec>
      <title id="t-2d59d76cddf4">
        <bold id="strong-b29b5ba1d37e4bb4a38e61b1f146a947">Bacteria used as probiotics</bold>
      </title>
      <list list-type="order">
        <list-item id="li-23f13afddd34">
          <p>Lactobacillus species</p>
        </list-item>
        <list-item id="li-9303977257d9">
          <p>Bifidobacterium</p>
        </list-item>
        <list-item id="li-df02057493b8">
          <p>Streptococcus</p>
        </list-item>
      </list>
      <sec>
        <title id="t-180545061658">Commercially used probiotics Lactobacilli and Bifidobacterium strains</title>
        <list list-type="bullet">
          <list-item id="li-15800348208f">
            <p><italic id="e-bd82f793d2f0">Lactobacillus rhamnosus</italic> GG</p>
          </list-item>
          <list-item id="li-c16a3b61b65a">
            <p><italic id="e-4bc3a82cd970">Lactobacillus johnsonii</italic> Lal</p>
          </list-item>
          <list-item id="li-6b0eacd6b867">
            <p><italic id="e-3d87939b3625">Lactobacillus acidophilus</italic> NCFM</p>
          </list-item>
        </list>
      </sec>
      <sec>
        <title id="t-154ad0d78d1f">Probiotic organisms <xref id="xref-1312b523b5fa40d3ad54c67a40772a55" rid="R162124026653876" ref-type="bibr">3</xref></title>
        <list list-type="bullet">
          <list-item id="li-3fdc752b4717">
            <p><italic id="e-5013456ef309">Lactobacillus </italic><italic id="e-262d22529bb0">casei </italic>CRL-43i Gilliland (La-Mo)</p>
          </list-item>
          <list-item id="li-89fcdc2ec703">
            <p><italic id="e-2346f82d9cb0">Lactobacillus reuteri </italic>SD</p>
          </list-item>
          <list-item id="li-f77b0038b793">
            <p><italic id="e-60d4b118ed08">Lactobacillus plantarum</italic> 299V</p>
          </list-item>
          <list-item id="li-3f0a5c1205e3">
            <p><italic id="e-7664dfcff95b">Lactobacillus</italic><italic id="e-d552b118f254"> rhamnosus</italic> 271</p>
          </list-item>
          <list-item id="li-f14237009eee">
            <p><italic id="e-4242ebbd4f73">Lactobacillus</italic><italic id="e-b63af2172f7f"> casei </italic>DN 014001</p>
          </list-item>
          <list-item id="li-9c8b789dbc94">
            <p><italic id="e-218196f2033b">Lactobacillus casei</italic> Shirota</p>
          </list-item>
          <list-item id="li-4d1a399bde97">
            <p><italic id="e-1a77b942f948">Lactobacillus delbruekii</italic> subsp bulgaricus 2038</p>
          </list-item>
          <list-item id="li-098c71f2e5cf">
            <p><italic id="e-3221a1fe5084">Streptococcus thermophilus</italic> 1131</p>
          </list-item>
          <list-item id="li-389c8e79e885">
            <p><italic id="e-5fabfba35fd2">Lactobacillus acidophilus </italic>SBT-2062</p>
          </list-item>
          <list-item id="li-db6a5dc9488e">
            <p><italic id="e-82879c7d621f">Bifidobacterium longum</italic> SBT-2928</p>
          </list-item>
          <list-item id="li-ed0be1986124">
            <p>
              <italic id="e-9a772cb0a129">Saccharomyces boulardii</italic>
            </p>
          </list-item>
          <list-item id="li-018cbe661b53">
            <p><italic id="e-25b68d79aa4f">B. longum </italic>BB536</p>
          </list-item>
          <list-item id="li-896732abf552">
            <p><italic id="e-5e87f33f6641">Bifidobacterium breve</italic> Yakult <xref id="xref-ea3e928f2b4d43f18788f1ba738e0439" rid="R162124026653878" ref-type="bibr">4</xref></p>
          </list-item>
        </list>
        <p id="paragraph-bc6724cadeea4533a7b7515dc2aff747">A recent study shows that probiotic effects are strain-specific; beneficial effects to one strain cannot be assumed to be provided by another strain, even when it belongs to the same species. A combination of strains creates a synergistic effect.</p>
      </sec>
    </sec>
    <sec>
      <title id="t-73b415d036fc">
        <bold id="strong-3d312fe11d0346c996462f460adfcb8f">Vehicle of Administration</bold>
      </title>
      <p id="paragraph-f48d9be0ed7c4cf1a1d2b890f633f7a5">The vehicle by which probiotics are ingested or delivered in the oral cavity, influence the cariogenic potential and the oral colonization of a probiotic. The most commonly used dietary lactobacilli are being consumed in milk products. <xref id="xref-3a9fdee6a0ab4c95aadf2fa4b0fd20e4" rid="R162124026653873" ref-type="bibr">5</xref></p>
      <p id="paragraph-5271ff08dce04ae090ba9759b2257820">Dairy foods containing probiotic bacteria include yogurt, culture-containing fluid milks, such as “Sweet Acidophilus Milk” and a few brands of cottage cheese. Dairy foods seem to fit naturally with probiotics because of the association of beneficial fermentation bacteria and fermented dairy products. Consumers associate fermented dairy products with live cultures and perceive a benefit in the presence of these cultures.</p>
      <p id="paragraph-21fa8e504c8241fd843152d9a13a20f7">Thus, the different vehicles for probiotics administration are – </p>
      <sec>
        <title id="title-eb2e4689453f455baffb4a9f33798d54">Milk Products</title>
        <list list-type="order">
          <list-item id="li-761db56e457d">
            <p>Milk drink  </p>
            <list list-type="order">
              <list-item id="li-894648b37b35">
                <p>Yogurt </p>
              </list-item>
              <list-item id="li-669ac6d59c8c">
                <p>Cheese </p>
              </list-item>
            </list>
          </list-item>
          <list-item id="li-432612e20cb1">
            <p>Fruit Juices </p>
          </list-item>
          <list-item id="li-e54e7c1b614c">
            <p>Lozenges </p>
          </list-item>
          <list-item id="li-80ed16ccf888">
            <p>Powder </p>
          </list-item>
          <list-item id="li-7ff685ff34d8">
            <p>Gelatine </p>
          </list-item>
          <list-item id="li-24b9dba68a9d">
            <p>Straw </p>
          </list-item>
          <list-item id="li-742f6e350d68">
            <p>Tablets </p>
          </list-item>
          <list-item id="li-6c8704391330">
            <p>A probiotic lozenge administered medical device. </p>
          </list-item>
          <list-item id="li-7d641c5aa006">
            <p>Capsules</p>
          </list-item>
        </list>
      </sec>
    </sec>
    <sec>
      <title id="t-7803125d8a33">
        <bold id="strong-83ae8e63c2614267b0bb84d05881fc24">Mechanism /interaction of probiotic organisms in oral </bold>
        <bold id="strong-851ae3a710174010a77663b6534ae6c0">cavity</bold>
      </title>
      <p id="paragraph-d1765a8c25db4129b6b207206a4c1c76">Probiotics may act direct interaction or indirect interaction on oral biofilm and microflora and vice versa.</p>
      <table-wrap id="table-wrap-51c8bf07cc6740b383220d1dca72b66c" orientation="portrait">
        <label>Table 1</label>
        <caption id="caption-daaed440086347ca86b86cf0c9c706ff">
          <title id="title-f47e9cbf7df14f8aa00f06f7c7268da3"/>
        </caption>
        <table id="table-e4cc79f47bfa4b3b8a268edde9ff410b" rules="rows">
          <colgroup/>
          <tbody id="table-section-7fec6672c8d44c34801e5d2379cabea2">
            <tr id="table-row-93adb38b4fc647fbad2fbad59c85dbdc">
              <td id="table-cell-f98918933a11459b87e8598e6aca4c8a" align="left">
                <p id="paragraph-1da0f98635a9451fbe10c32f5e6cb43d">
                  <bold id="s-c658e0c6c0b3">Direct interactions in dental plaque</bold>
                </p>
              </td>
              <td id="table-cell-1d9f114e0496481581183fc227953543" align="left">
                <p id="paragraph-9d4566f24993463db820d01cb445ae5e"> </p>
              </td>
              <td id="table-cell-677b7733c1ea4074a0d6a47afdc9395a" align="left">
                <p id="paragraph-add6792585864aa78337fda074fdf262">
                  <bold id="s-ba2c5d879659">Indirect probiotic actions in the oral cavity</bold>
                </p>
              </td>
            </tr>
            <tr id="table-row-75f71b77fbd44fb1b33fbb4ba236b496">
              <td id="table-cell-4665d240f8cb48b6aa8e2e0f75aefdfe" align="left">
                <p id="paragraph-19fb6c263af94745a8715888b4c4a089"> • Involvement in binding of oral micro-organisms to proteins (biofilm formation) </p>
                <p id="p-d6cb5bdc2353">• Action on plaque formation and on its complex ecosystem by competing and intervening with bacteria-to bacteria attachments </p>
                <p id="p-76205c77bbee">• Involvement in metabolism of substrates (competing with oral micro-organisms of substrates available) </p>
                <p id="p-e546d8acf515">• Production of chemicals that inhibit oral bacteria (antimicrobial substances)</p>
              </td>
              <td id="table-cell-9e24ad09dc1a4facb94d0432046fb227" align="left">
                <p id="paragraph-b3c633d4a6604b799199469571a414f3"> </p>
              </td>
              <td id="table-cell-12c4be1eeb524a94b3668d02ad9355c9" align="left">
                <p id="paragraph-173b793463e54888831c6588ec0a5eee"> • Modulating systemic immune function selection pressure on developing oral microflora colonization by less pathogenic species. </p>
                <p id="p-fa4cd162c291">• Reduction of malodor. </p>
                <p id="p-1ad8eef1b0b8"><bold id="strong-078f0b74e20d4be5935e9f6c3b9e89d8">Other effects</bold> </p>
                <p id="p-4a7d0fd22fe3">• Inhibit growth of pathogenic bacteria </p>
                <p id="p-6168e9cc838a">• Enhance growth of other friendly bacteria. </p>
                <p id="p-d8778e1dd5eb">• Reduce toxins </p>
                <p id="p-1da3704fd8aa">• Increased immunity / bacterial resistance </p>
                <p id="p-59e18de365bd">• Produce vitamins and other nutritional factors </p>
                <p id="p-58e76d961614">• Reduce cholesterol </p>
                <p id="p-0ac4fa4016cd">• Alleviate flatulence </p>
              </td>
            </tr>
          </tbody>
        </table>
      </table-wrap>
      <p id="paragraph-949bce5b73b045c896a774e51ae372e2">Hence, probiotics have the following functions in the oral cavity.</p>
      <list list-type="order">
        <list-item id="li-c1e283aaca0a">
          <p>Prevent dental caries</p>
        </list-item>
        <list-item id="li-1ab344b12014">
          <p>Improves periodontal health</p>
        </list-item>
        <list-item id="li-b5f7d3a0ac86">
          <p>Controls microbial infections</p>
        </list-item>
        <list-item id="li-b3455c1b8d22">
          <p>Treat halitosis</p>
        </list-item>
      </list>
    </sec>
    <sec>
      <title id="title-99bd3b586dc7432db48d6aa0cd6c004d">Conclusion</title>
      <p id="paragraph-543643319f47409eba50a693aa21344e">The results of this review confirm that more studies are necessary to evaluate the efficacy of probiotics with correct methodological design, in broader population samples, and over longer periods of time. Comparative trials of different strains of probiotic species would be recommended.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <title>References</title>
      <ref id="R162124026653877">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Haukioja</surname>
              <given-names>A</given-names>
            </name>
            <collab/>
          </person-group>
          <article-title>Probiotics and Oral Health</article-title>
          <source>European Journal of Dentistry</source>
          <year>2010</year>
          <volume>4</volume>
          <issue>3</issue>
          <fpage>348</fpage>
          <lpage>355</lpage>
          <issn>1305-7456</issn>
          <publisher-name>Georg Thieme Verlag KG</publisher-name>
          <uri>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897872/</uri>
        </element-citation>
      </ref>
      <ref id="R162124026653875">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Eckert</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Sullivan</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Shi</surname>
              <given-names>W</given-names>
            </name>
            <collab/>
          </person-group>
          <article-title>Targeted Antimicrobial Treatment to Re-establish a Healthy Microbial Flora for Long-term Protection</article-title>
          <source>Advances in Dental Research</source>
          <year>2012</year>
          <volume>24</volume>
          <issue>2</issue>
          <fpage>94</fpage>
          <lpage>97</lpage>
          <issn>0895-9374</issn>
          <publisher-name>SAGE Publications</publisher-name>
          <uri>https://doi.org/10.1177%2F0022034512453725</uri>
        </element-citation>
      </ref>
      <ref id="R162124026653876">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Goldman</surname>
              <given-names>Ann S</given-names>
            </name>
            <name>
              <surname>Yee</surname>
              <given-names>Robert</given-names>
            </name>
            <name>
              <surname>Holmgren</surname>
              <given-names>Christopher J</given-names>
            </name>
            <name>
              <surname>Benzian</surname>
              <given-names>Habib</given-names>
            </name>
            <collab/>
          </person-group>
          <article-title>Global affordability of fluoride toothpaste</article-title>
          <source>Globalization and Health</source>
          <year>2008</year>
          <volume>4</volume>
          <issue>1</issue>
          <fpage>7</fpage>
          <issn>1744-8603</issn>
          <publisher-name>Springer Science and Business Media LLC</publisher-name>
          <uri>https://doi.org/10.1186/1744-8603-4-7</uri>
        </element-citation>
      </ref>
      <ref id="R162124026653878">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Thankappan</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Sherin</surname>
              <given-names>N</given-names>
            </name>
            <name>
              <surname>Thomas</surname>
              <given-names>V</given-names>
            </name>
            <collab/>
          </person-group>
          <article-title>Probiotics -New horizons in dentistry</article-title>
          <source>Journal of Indian dental association</source>
          <year>2008</year>
          <volume>2</volume>
          <issue>6</issue>
          <fpage>153</fpage>
          <lpage>155</lpage>
        </element-citation>
      </ref>
      <ref id="R162124026653873">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Teughels</surname>
              <given-names>Wim</given-names>
            </name>
            <name>
              <surname>Essche</surname>
              <given-names>Mark Van</given-names>
            </name>
            <name>
              <surname>Sliepen</surname>
              <given-names>Isabelle</given-names>
            </name>
            <name>
              <surname>Quirynen</surname>
              <given-names>Marc I</given-names>
            </name>
            <collab/>
          </person-group>
          <article-title>Probiotics and oral healthcare</article-title>
          <source>Periodontology 2000</source>
          <year>2008</year>
          <volume>48</volume>
          <issue>1</issue>
          <fpage>111</fpage>
          <lpage>147</lpage>
          <issn>0906-6713</issn>
          <publisher-name>Wiley</publisher-name>
          <uri>https://doi.org/10.1111/j.1600-0757.2008.00254.x</uri>
        </element-citation>
      </ref>
    </ref-list>
  </back>
</article>
